M'zaka za m'ma 1990, Pfizer adatsogola pakupanga ndikulemba mndandanda wa chipolopolo choyamba chapadziko lonse lapansi chosakhala gelatin, chopangira chachikulu chomwe ndi cellulose ester "hydroxypropyl methyl cellulose" kuchokera ku zomera.Chifukwa mtundu watsopano wa kapisozi ulibe zosakaniza zilizonse zanyama, zimatamandidwa ndi makampani ngati "kapisozi wamaluwa".Pakali pano, ngakhale kuchuluka kwa malonda a makapisozi a zomera pamsika wapadziko lonse wa makapisozi sikuli kwakukulu, chitukuko chake ndi champhamvu kwambiri, ndi kukula kwa msika.
　　
"Ndi chitukuko cha sayansi ya zamankhwala ndi zamakono ndi sayansi yokhudzana ndi sayansi, kufunikira kwa mankhwala opangira mankhwala pakupanga mankhwala opangira mankhwala kwadziwika pang'onopang'ono, ndipo malo a pharmacy akuwonjezeka."Ouyang Jingfeng, wofufuza wothandizira pa Chinese Academy of Chinese Medical Sciences, adanena kuti othandizira mankhwala samangodziwa mtundu wa mitundu yatsopano ya mlingo ndi kukonzekera kwatsopano kwa mankhwala, komanso amathandizira kukonzekera kupanga, kukhazikika, kusungunuka. , onjezerani kusungunuka, kutulutsa kumasulidwa, kumasulidwa kosalekeza, kumasulidwa koyendetsedwa, kuyang'ana, nthawi, kuika, kuchitapo kanthu mwamsanga, kogwira mtima komanso kwa nthawi yaitali, ndipo m'lingaliro lina, chitukuko cha chothandizira chatsopano chingapangitse chitukuko cha gulu lalikulu. mawonekedwe a mlingo, kuwongolera kuchuluka kwa mankhwala atsopano ndi kukonzekera, ndipo tanthauzo lake limaposa chitukuko cha mankhwala atsopano.Mu mankhwala mlingo mawonekedwe monga kirimu mapiritsi, mapiritsi, jakisoni, ndi makapisozi, makapisozi akhala waukulu mlingo mitundu ya m`kamwa olimba kukonzekera chifukwa cha bioavailability awo mkulu, kuwongolera bata la mankhwala, ndi Maudindo yake ndi kumasulidwa kwa mankhwala.

Pakali pano, chachikulu zopangira kupanga makapisozi ndi gelatin, gelatin amapangidwa ndi hydrolysis nyama mafupa ndi zikopa, ndi kwachilengedwenso macromolecule ndi ternary ozungulira dongosolo, ndi biocompatibility wabwino ndi katundu thupi ndi mankhwala.Komabe, makapisozi a gelatin alinso ndi zoletsa zina pakugwiritsa ntchito, ndipo kupanga zida zatsopano za zipolopolo za kapisozi zomwe sizinali zanyama kwakhala kotentha kwambiri pakufufuza kwaposachedwa kwamankhwala opangira mankhwala.Wu Zhenghong, pulofesa wa pa yunivesite ya China Pharmaceutical University, ananena kuti chifukwa cha “matenda amisala a ng’ombe” m’mayiko a ku Ulaya monga Britain, France ndi Netherlands m’zaka za m’ma 1990 (kuphatikizapo Japan ku Asia, amenenso anapeza ng’ombe zamisala ndi matenda amisala). , anthu a m’mayiko a azungu anali ndi chidaliro champhamvu cha nyama ya ng’ombe ndi ng’ombe zongopangidwa ndi ng’ombe (gelatin ndi imodzi mwa izo).Kuphatikiza apo, Abuda ndi odyetsera zamasamba amalimbananso ndi makapisozi a gelatin opangidwa kuchokera kuzinthu zopangira nyama.Poganizira izi, makampani ena akunja a makapisozi adayamba kuphunzira zida zatsopano za zipolopolo za makapisozi omwe si a gelatin ndi nyama zina, ndipo ulamuliro wa makapisozi amtundu wa gelatin unayamba kugwedezeka.

Kupeza zida zatsopano zopangira makapisozi osakhala a gelatin ndiye njira yomwe ikukulirakulira kwamankhwala othandizira.Ouyang Jingfeng adanenanso kuti zopangira za makapisozi a zomera pakali pano ndi hydroxypropyl methylcellulose, wowuma wosinthidwa ndi zomatira za hydrophilic polymer chakudya, monga gelatin, carrageenan, xanthan chingamu ndi zina zotero.Makapisozi a Hydroxypropyl methyl cellulose ali ndi kusungunuka kofanana, kupasuka ndi bioavailability kwa makapisozi a gelatin, pomwe ali ndi zabwino zomwe makapisozi a gelatin alibe, koma kugwiritsa ntchito pano sikunali kokwanira, makamaka chifukwa cha kukwera mtengo kwa mankhwalawa, poyerekeza ndi gelatin. hydroxypropyl methyl cellulose kapisozi kapisozi yaiwisi mtengo ndi apamwamba, kuwonjezera pa pang'onopang'ono gel osakaniza liwiro, kuchititsa mkombero yaitali kupanga.

Pamsika wapadziko lonse wamankhwala, makapisozi a mbewu ndi amodzi mwazinthu zomwe zikukula mwachangu.Wu Zhenghong adanena kuti poyerekezera ndi makapisozi a gelatin, makapisozi a zomera ali ndi ubwino wodziwikiratu: Choyamba, palibe kutsutsana.Makapisozi a zomera amakhala ndi inertness yamphamvu ndipo sizovuta kulumikizana ndi magulu a aldehyde kapena mankhwala ena.Yachiwiri ndi yoyenera mankhwala osamva madzi.Chinyezi cha makapisozi a zomera nthawi zambiri chimayendetsedwa pakati pa 5% ndi 8%, ndipo sikophweka kuchitapo kanthu ndi mankhwala ndi zomwe zili mkatimo, ndipo madzi otsika amatsimikizira kukhazikika kwa zinthu zomwe zimakhala ndi hygroscopic zomwe zimakhudzidwa ndi chinyezi.Chachitatu ndi kugwirizana bwino ndi excipients waukulu mankhwala.Makapisozi amasamba amalumikizana bwino ndi lactose, dextrin, wowuma, cellcrystalline cellulose, magnesium stearate ndi zina zazikulu zomwe zimagwiritsidwa ntchito popanga mankhwala.Chachinayi ndi kukhala ndi malo omasuka odzaza.Makapisozi obzala ali ndi zofunikira zotayirira pamalo ogwirira ntchito zomwe zadzaza, kaya ndi zofunika pa malo ogwirira ntchito kapena kuchuluka kwapamakina pamakina, zomwe zingachepetse mtengo wogwiritsa ntchito.
　
　
"M'dziko lapansi, makapisozi a zomera akadali akhanda, mabizinesi ochepa okha ndi omwe angathe kupanga makapisozi amankhwala a zomera, ndipo m'pofunika kulimbikitsanso kafukufuku wazinthu zopanga zinthu ndi zina, komanso kuwonjezera kuyesetsa kwa msika."Ouyang Jingfeng adanenanso kuti pakalipano, kutulutsa kwa makapisozi a gelatin ku China kwafika pamalo oyamba padziko lapansi, pomwe gawo la msika wazinthu zamakapuleti a zomera akadali otsika.Komanso, chifukwa ndondomeko mfundo kubala makapisozi sizinasinthe kwa zaka zoposa zana, ndi mosalekeza kusintha zida lakonzedwa molingana ndi kupanga gelatin, momwe ntchito ndondomeko ndi zipangizo pokonzekera makapisozi gelatin kukonzekera chomera. makapisozi akhala cholinga cha kafukufuku, zomwe zimaphatikizapo kusanthula kwapadera kwa zinthu zamachitidwe monga mamasukidwe akayendedwe, ma rheological properties ndi viscoelasticity ya zinthu.
　　

Ngakhale sizingatheke kuti makapisozi a zomera alowe m'malo mwa makapisozi amtundu wa gelatin, makapisozi a zomera ali ndi ubwino wampikisano wamankhwala aku China, kukonzekera kwachilengedwe komanso zakudya zogwira ntchito.Zhang Youde, injiniya wamkulu pa School of Materials Science and Engineering ya Beijing Institute of Technology, akukhulupirira kuti ndi kumvetsa mozama kwa anthu makapisozi a zomera ndi kusintha kwa malingaliro a mankhwala a anthu, kufunikira kwa msika wa makapisozi a zomera kudzakula mofulumira.