(1)Zida zopangira

Zopangira za HPMC hollow capsule zimachokera ku fiber zachilengedwe zachilengedwe (mtengo wa paini), womwe ndi wokonda zachilengedwe, wotetezeka komanso wodalirika.

Gelatin hollow capsule imachokera ku collagen mu zikopa za nyama ndi mafupa.Mu m'zigawo ndondomeko, kuchuluka kwa zigawo za mankhwala anawonjezera, amene n'zosavuta kuyambitsa tizilombo toyambitsa matenda a misala ng'ombe matenda ndi phazi ndi pakamwa matenda, etc.,.M'zaka zaposachedwa, chochitika cha "Poison Capsule" chawonetsa mavuto ambiri a makapisozi amtundu wa gelatin, monga "glue lachikopa labuluu" lomwe limawululidwa ndi media, zomwe zimapangitsa kuti chromium mu kapisozi ipitirire muyezo.

(2) Kugwiritsa Ntchito & Kukhazikika Kwamankhwala

HPMC ndi chochokera ku cellulose yokhala ndi inertness yamphamvu, kugwiritsa ntchito kwambiri, kukhazikika kwa mankhwala, osalumikizana ndi mankhwala okhala ndi aldehyde, komanso osachedwa kutha.

Lysine amakhalabe mu gelatin, Mukamagwiritsa ntchito gelatin mu kapisozi, padzakhala azingokhala akuchedwa chodabwitsa.Mankhwala omwe amachepetsa kwambiri amakhala ndi Maillard reaction ndi gelatin (Browning Reaction).Ngati mankhwala okhala ndi aldehyde, reductive shuga-based chemicals, kapena vitamini C, ndiye kuti si oyenera kugwiritsidwa ntchito mu kapisozi dzenje la gelatin.

(3) M’madzi

Madzi omwe ali mu kapule ya gelatin hollow ndi pafupifupi 12.5% ​​mpaka 17.5%.Gelatin capsule yokhala ndi madzi ambiri imakonda kuyamwa chinyontho cha mankhwalawo kapena kuyamwa madzi ndi kudzaza kwake, kupangitsa kapisozi kukhala wofewa kapena wonyezimira, kumakhudza mankhwala odzaza okha.

Madzi omwe ali mu kapisozi kakang'ono ka HPMC ndi pafupifupi 3% mpaka 9%, zomwe sizingafanane ndi zomwe zadzaza, ndipo zimatha kukhala ndi makhalidwe abwino monga kulimba pamene mukudzaza mankhwala osokoneza bongo, makamaka oyenera hygroscopicity ndi kudzaza chinyezi. mankhwala osokoneza bongo.

(4) Zotsalira zosungira

Chigawo chachikulu cha gelatin hollow capsule ndi mapuloteni, omwe ndi osavuta kuswana mabakiteriya ndi tizilombo toyambitsa matenda.Zotetezera ndi bacteriostatic agents, zikhoza kusiyidwa mu kapisozi kuti ziteteze kukula kwa tizilombo toyambitsa matenda panthawi yopanga.Ngati kuchuluka kwake kupitilira mulingo wina, zomwe zili ndi arsenic zimatha kupitilira.Pa nthawi yomweyi, makapisozi amtundu wa gelatin ayenera kutsekedwa ndi ethylene oxide akamaliza kupanga, ndipo padzakhala chlorohydrin pambuyo pa kutseketsa kwa ethylene oxide.Pomwe zotsalira za Chlorohydrin ndizoletsedwa kugwiritsidwa ntchito.

HPMC dzenje makapisozi safuna kuwonjezera zoteteza aliyense mu ndondomeko kupanga, safuna kuti chosawilitsidwa, angathe kukwaniritsa mfundo za dziko, ndi wathanzi makapisozi wobiriwira popanda zotsalira ndi zoteteza.

(5) Kusungirako

Makapisozi opanda kanthu a HPMC amakhala ndi malo osungiramo otayirira, pa kutentha kwa 10 mpaka 30 ° C, ndi chinyezi chapakati pa 35% ndi 65%, chomwe sichimafewetsa kapena kuuma ndikukhala chiphuphu.The HPMC dzenje kapisozi ali ndi friability wa ≤ 2% pa chinyezi 35% ndi kapisozi kusintha ≤ 1% pa kutentha 80 ° C;Kusunga ndi kunyamula m'madera onse anyengo si vuto.

Makapisozi a gelatin amatha kumamatira pansi pa chinyezi chambiri;kuuma kapena friability pansi pa chinyezi chochepa, ndipo kudalira kwambiri kutentha ndi chinyezi cha malo osungiramo

(6) Wokonda zachilengedwe

The m'zigawo za HPMC dzenje kapisozi zopangira ikuchitika ndi thupi m'zigawo.Amachotsedwa mumtengo wa paini ndipo samatulutsa fungo lowola.Amachepetsanso kwambiri madzi omwe amagwiritsidwa ntchito komanso amachepetsa kuwononga chilengedwe.Palibe zinthu zovulaza zomwe zimawonjezeredwa panthawiyi ndipo palibe kuwononga chilengedwe.

Gelatin hollow makapisozi amapangidwa ndi khungu la nyama ndi fupa ngati zopangira, zomwe zimakhudzidwa ndi mankhwala ndi kufufumitsa.Njirayi imaphatikizapo zigawo zambiri za mankhwala, zimatulutsa fungo lalikulu panthawi yopanga, ndipo zimagwiritsa ntchito madzi ambiri.Kutulutsa kuipitsa kwakukulu;Komanso zobwezeretsanso zinyalala za gelatin ndizochepa, ndipo zowononga zambiri zimapangidwa pakataya zinyalala zake.

(7) Kudzipatula kukhudzana ndi mpweya wakunja

The zopangira katundu wa HPMC dzenje makapisozi amaona kuti bwino kudzipatula zomwe zili kunja ndi kupewa mavuto ndi mpweya, ndipo alumali moyo wake nthawi zambiri 24 miyezi.

Gelatin capsule imakhala ndi nthawi yogwira ntchito ya miyezi 18, pomwe palinso nthawi yosungiramo musanagwiritse ntchito imapangitsa kapisozi kukhala ndi moyo wamfupi wa alumali, womwe umakhudza mwachindunji moyo wa alumali wa mankhwala.

(8) Kulepheretsa kukula kwa bakiteriya

Zopangira zazikulu za HPMC makapisozi opanda kanthu ndi ulusi wazomera, zomwe sizimangochulukitsa mabakiteriya, komanso zimalepheretsa kukula kwa bakiteriya.Kuyesera kwawonetsa kuti makapisozi opanda kanthu a HPMC amatha kusungidwa m'malo ambiri kwa nthawi yayitali, ndipo kuchuluka kwa tizilombo toyambitsa matenda kumatha kusungidwa mulingo woyenera.

Zopangira zazikulu za gelatin hollow capsule ndi collagen, ndipo collagen ndi sing'anga ya chikhalidwe cha mabakiteriya, yomwe imathandiza kuti mabakiteriya achuluke.Ngati mankhwalawa ndi osayenera, chiwerengero cha mabakiteriya chidzapitirira muyezo ndipo chidzachulukana.

TSIRIZA.